For an oocyte to become All set for fertilization and development into an embryo, the ideal list of genes ought to be turned on. Namekawa suspected that this pre-programming of your oocyte genome happens in numerous stages — the first a person starting up around the time a woman is born. He thought that chromatin remodeling proteins did Considerably of this get the job done, by shifting spools close to.
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Using the GCRLE grant, Munakata and Namekawa will glimpse far more carefully at how oocytes are genomically primed and stored for later use. They may investigate the function of the chromatin remodeler in oocyte survival and fertility.
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